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What is Somazina  (citicoline)?

The above information is for your reference only. It cannot be used in place of a consultation with a medical professional nor as a basis of self-diagnosis or for treatment decision. Only your physician can provide you with accurate diagnosis and appropriate treatment.

References   
1.  Grieb P. Neuroprotective properties of citicoline: facts, doubts and unresolved issues. CNS Drugs 201428:185-193.  2. Weiss GB. Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci 1995;56:637-660.  3. Secades JJ. Citicoline: pharmacological and clinical review, 2016 update. Rev Neurol 2016;63 (Suppl 3):S1-S73.  4. Álvarez-Sabín J and Román GC. The Role of citicoline in neuroprotection and neurorepair in ischemic stroke. Brain Sci 2013;3:1395-1414.  5. Farooqui AA, Horrocks LA and Farooqui T. Glycerophospholipids in brain: their metabolism, incorporation to membranes, functions, and involvement in neurological disorders. Chem Phys Lipids 2000;106:1-29.  6. Adibhatla RM and Hatcher JF. Role of lipids in brain injury and diseases. Future Lipidol 2007;2:403-422.  7. Klein J. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids. J Neural Transm 2000;107:1027-1063.

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What does citicoline actually do to our bodies?

Why do patients with stroke and TBI need citicoline?

There are various conditions in which a phospholipid loss or decreased synthesis occurs, leading to an impairment in cell functions that may have a pathophysiological impact  . Impaired cell membrane and phospholipid metabolism have been implicated in the pathophysiology of cerebral edema and TBI, as well as cerebral hypoxia and cerebral ischemia  . Moreover, it has been shown that there are certain changes in neural membranes and metabolism of structural phospholipids associated with brain aging and cognitive impairment  .

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Somazina  is a branded form of citicoline. Citicoline is the generic name of the pharmaceutical substance that is chemically known as cytidine 5'-diphosphocholine (CDP-choline).  It is identical to the natural intracellular precursor of the phospholipid phosphatidylcholine  . Citicoline is an essential intermediate in the synthesis of structural phospholipids of cell membranes  . It is also related to acetylcholine metabolism. Thus, administration of citicoline is an exogenous source of choline and cytidine  .

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Citicoline is crucial in the synthesis of structural phospholipids, particularly phosphatidylcholine, in cell membranes. Phospholipids are essential constituents of cells, and the continuous synthesis of phospholipids is needed to ensure the adequate function of cell membranes. In the brain, structural phospholipids in the membranes of nerve cells are essential for adequate brain maturation, and phosphatidylcholine is an important molecule for growth and regeneration of nerve cells    .

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