The above information is for your reference only. It cannot be used in place of a consultation with a medical professional nor as a basis of self-diagnosis or for treatment decision. Only your physician can provide you with accurate diagnosis and appropriate treatment.

Clinical Efficacy in Stroke Patients

Somazina  improves overall recovery


Data analysis of a total of 1,372 patients with moderate-to-severe acute stroke from 4 clinical trials showed that treatment with oral citicoline within the first 24 hours after symptom onset increased the chance of complete recovery at 3 months  .



Long-term Somazina prevents decline in cognitive function


Researchers observed that citicoline treatment for 2 years after the first stroke improved overall cognitive function in a clinical trial involving 163 patients  .


Cognitive functions evaluated  :


•    Attention, executive function
•    Language
•    Memory
•    Spatial perception
•    Dexterity
•    Orientation to time


Somazina helps patients regain their independence


Data analysis of a total of 4,420 patients with acute stroke from 10 clinical trials demonstrated that treatment with citicoline was associated with an increased rate of patient independence  .



Somazina  has been clinically studied to treat cognitive and neurological disorders associated with stroke.


1. Warach S, Pettigrew LC, Dashe JF, et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 2000;48:713-722.  2. Dávalos A, Castillo J, Álvarez-Sabín J, et al. Oral citicoline in acute ischemic stroke: An individual patient data pooling analysis of clinical trials. Stroke 2002;33:2850-2857.  3. Álvarez-Sabín J, Santamarina E, Maisterra O, et al. Long-term treatment with citicoline prevents cognitive decline and predicts a better quality of life after a first ischemic stroke. Int J Mol. Sci 2016;17:390.  4. Álvarez-Sabín J, Ortega G, Jacas C, et al. Long-term treatment with citicoline may improve poststroke vascular cognitive impairment. Cerebrovasc Dis 2013;35:146-154.  5. Secades JJ, Álvarez-Sabín J, Castillo J, et al. Citicoline for acute ischemic stroke: A systematic review and formal meta-analysis of randomized, double-blind, and placebo-controlled trials. J Stroke Cerebrovasc Dis 2016;25:1984-1996.

Somazina  reduces the volume of stroke-damaged brain tissue


Researchers observed that oral citicoline helped reduce the volume of brain tissue that had been damaged through acute stroke in a clinical trial involving 81 patients .